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DeepMind releases AlphaGenome 2, capable of predicting the effects of mutations in specific cell types

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12 Nov
  1. The Decoder
    Google Deepmind released AlphaGenome 2, advancing genomic AI from organizational-level prediction to single-cell type resolution.

    AlphaGenome 2 predicts the effects of genetic variations on specific human cell types, discovering nearly double the related gene changes compared to its predecessor. The model is trained on data encompassing 107 million cell phenotypes across 68 tissues, achieving single-cell-level precise predictions by combining DNA sequences with specific biological states as input.

  2. ITHome · AI
    Google DeepMind releases next-generation genome AI model AlphaGenome 2: from tissue prediction to single-cell analysis, identifying gene expression variation capabilities nearly double

    Google DeepMind has launched the AlphaGenome 2 model, which can predict the effects of DNA variations on specific cell types, nearly doubling its ability to identify gene expression variations to 30% (from 16%), and accurately predicting the direction of gene expression changes to 43% (from 23%). It supports cross-modal data inference and has opened API access to non-commercial research.

  3. MarkTechPost
    Google DeepMind releases AlphaGenome 2 for cell-type specific variant effect prediction

    Google DeepMind releases AlphaGenome 2, a DNA model that predicts the effects of specific cell type mutations. The model reads 1 Mb DNA and target cell state, significantly improving single-cell eQTL prediction performance through conditional sequence to functional architecture, increasing recall from 23% to 43% on the TenK10K benchmark, and can adapt to unseen datasets without fine-tuning.

11 Nov
  1. Google DeepMindFeatured
    DeepMind releases AlphaGenome 2, predicting DNA variation impacts by cell type

    Google DeepMind releases AlphaGenome 2, a conditional DNA sequence model that can predict the impact of DNA mutations on gene expression for specific cell types or states.

  2. The Verge · AI
    Google DeepMind has released the AlphaGenome 2 model, analyzing how DNA affects different cells.

    Google DeepMind releases AlphaGenome 2 model, predicting gene variation impacts on different cell types and states by analyzing over 100 million cell outline data, identifying nearly double the variable gene expression mutations compared to the previous generation model

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